How histological features of basal cell carcinomas influence image quality in optical coherence tomography
- 19 May 2011
- journal article
- Published by Wiley in Journal of Biophotonics
- Vol. 4 (7-8), 544-551
- https://doi.org/10.1002/jbio.201100006
Abstract
Optical coherence tomography (OCT) has the potential to diagnose and measure the depth of nonmelanoma skin cancer (NMSC) in skin, but some lesions appear blurred in OCT images. The aim of this study is to identify histological characteristics of basal cell carcinomas (BCC) that correlate with good quality OCT images of the same lesions. A total of 34 patients with BCC were OCT scanned. The influence of histology parameters (e.g. inflammation, sun damage of skin, carcinoma cell size) on OCT image quality was studied by comparing 15 BCC lesions easily identified compared to 19 BCC lesions that produced only blurred in OCT images. Inflammation was more pronounced in blurred OCT images, whereas solar elastosis dominated in easily identified lesions. Hyperkeratosis did not impair imaging significantly. OCT image quality of BCC may depend on specific histology parameters.Keywords
This publication has 27 references indexed in Scilit:
- Improved quality of optical coherence tomography imaging of basal cell carcinomas using speckle reductionExperimental Dermatology, 2009
- Surgical Monotherapy Versus Surgery Plus Adjuvant Radiotherapy in High-Risk Cutaneous Squamous Cell CarcinomaDermatologic Surgery, 2009
- Pre-surgical high resolution ultrasound of facial basal cell carcinoma: correlation with histologyCancer Imaging, 2008
- Using optical coherence tomography to evaluate skin sun damage and precancerLasers in Surgery and Medicine, 2007
- The Use of High-Frequency Ultrasound in the Evaluation of Superficial and Nodular Basal Cell CarcinomasDermatologic Surgery, 2007
- Diagnosis of Nonmelanoma Skin Cancer/Keratinocyte Carcinoma: A Review of Diagnostic Accuracy of Nonmelanoma Skin Cancer Diagnostic Tests and TechnologiesDermatologic Surgery, 2007
- Correlation of Thickness of Basal Cell Carcinoma by Optical Coherence Tomography In Vivo and Routine Histologic Findings: A Pilot StudyDermatologic Surgery, 2007
- Optical coherence tomography for the characterization of basal cell carcinoma in vivo: A pilot studyJournal of the American Academy of Dermatology, 2006
- Optical coherence tomography for ultrahigh resolution in vivo imagingNature Biotechnology, 2003
- High frequency, high resolution B-scan ultrasound in the assessment of skin tumoursBritish Journal of Dermatology, 1993