Morphology of basal cell carcinoma in high definition optical coherence tomography: en‐face and slice imaging mode, and comparison with histology
- 28 April 2012
- journal article
- Published by Wiley in Journal of the European Academy of Dermatology and Venereology
- Vol. 27 (1), e97-e104
- https://doi.org/10.1111/j.1468-3083.2012.04551.x
Abstract
Optical coherence tomography (OCT) allows real-time, in vivo examination of basal cell carcinoma (BCC). A new high definition OCT with high lateral and axial resolution in a horizontal (en-face) and vertical (slice) imaging mode offers additional information in the diagnosis of BCC and may potentially replace invasive diagnostic biopsies. To define the characteristic morphologic features of BCC by using high definition optical coherence tomography (HD-OCT) compared to conventional histology. A total of 22 BCCs were examined preoperatively by HD-OCT in the en-face and slice imaging mode and characteristic features were evaluated in comparison to the histopathological findings. The following features were found in the en-face mode of HD-OCT: lobulated nodules (20/22), peripheral rimming (17/22), epidermal disarray (21/22), dilated vessels (11/22) and variably refractile stroma (19/22). In the slice imaging mode the following characteristics were found: grey/dark oval structures (18/22), peripheral rimming (13/22), destruction of layering (22/22), dilated vessels (7/22) and peritumoural bright stroma (11/22). In the en-face mode the lobulated structure of the BCC was more distinct than in the slice mode compared to histology. HD-OCT with a horizontal and vertical imaging mode offers additional information in the diagnosis of BCC compared to conventional OCT imaging and enhances the feasibility of non-invasive diagnostics of BCC.Keywords
This publication has 21 references indexed in Scilit:
- Peritumoral clefting in basal cell carcinoma: correlation of in vivo reflectance confocal microscopy and routine histologyJournal of Cutaneous Pathology, 2010
- Imaging of periocular basal cell carcinoma using en face optical coherence tomography: a pilot studyBritish Journal of Ophthalmology, 2010
- Improved quality of optical coherence tomography imaging of basal cell carcinomas using speckle reductionExperimental Dermatology, 2009
- In vivothickness measurement of basal cell carcinoma and actinic keratosis with optical coherence tomography and 20-MHz ultrasoundBritish Journal of Dermatology, 2009
- Machine‐learning classification of non‐melanoma skin cancers from image features obtained by optical coherence tomographySkin Research and Technology, 2008
- Trends in incidence of skin basal cell carcinoma. Additional evidence from a UK primary care database studyInternational Journal of Cancer, 2007
- Optical coherence tomography for the characterization of basal cell carcinoma in vivo: A pilot studyJournal of the American Academy of Dermatology, 2006
- Applications of optical coherence tomography in dermatologyJournal of Dermatological Science, 2005
- Sensitivity and specificity of reflectance-mode confocal microscopy for in vivo diagnosis of basal cell carcinoma: A multicenter studyJournal of the American Academy of Dermatology, 2004
- Real-time, in vivo confocal reflectance microscopy of basal cell carcinomaJournal of the American Academy of Dermatology, 2002