Ochratoxin A in human blood plasma samples from apparently healthy volunteers in Nanjing, China
- 3 February 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Mycotoxin Research
- Vol. 36 (3), 269-276
- https://doi.org/10.1007/s12550-020-00387-8
Abstract
This study was conducted to investigate the exposure to ochratoxin A (OTA) of populations living in Nanjing, China. Plasma samples were collected from 147 healthy adults (age 18–63 years) and analyzed for OTA by a reliable and sensitive ultra-high-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method (limit of detection 0.04 ng/mL). After enzymatic hydrolysis by β-glucuronidase/arylsulfatase, OTA was detected in 80.9% plasma samples with mean concentration of 0.26 ± 0.59 ng/mL (range 0.04–6.59 ng/mL). The estimated daily intakes of OTA based on plasma concentrations (mean 0.51 ng/kg bw/day, max 12.99 ng/kg bw/day) were lower than the tolerable daily intake published by European Food Safety Authority (EFSA) or Joint FAO/WHO Expert Committee on Food Additives (JFECFA) indicative of rare risks related to the OTA exposure in the investigated area. This study provides a valuable insight on human exposure to OTA in China. Further studies in children and elder people and in adult cohorts from other regions are recommended.Keywords
Funding Information
- National Natural Science Foundation of China (31671950, 31972178)
- Science and Technology Commission of Shanghai Municipality (18395810100)
- Shanghai Municipal Agricultural Commission (20170130)
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