Ochratoxin A in human plasma in Morocco: a preliminary survey
- 1 May 2002
- journal article
- Published by SAGE Publications in Human & Experimental Toxicology
- Vol. 21 (5), 241-245
- https://doi.org/10.1191/0960327102ht249oa
Abstract
Available epidemiological information seems to indicate that Balkan endemic nephropathy is associated with consumption patterns involving foodstuffs contaminated with ochratoxin A (OTA) and with a higher frequency of OTA-positive blood samples. The aim of this preliminary study was to assess OTA concentrations in human plasma in Morocco. Therefore, samples from 309 healthy volunteers (213 males, 96 females) were analysed. The analyses revealed that 60% of the human plasma sampled was positive for OTA (61.5% in the male and 56% in the female population), and an average concentration of 0.29 ng// /mL (0.31 ng///mL in males, 0.26 ng// /mL in females). The highest concentration found was 6.59 ng// /mL. The results suggest that the Moroccan population is exposed to OTA, even though the OTA plasma levels are lower than that reported in some North African countries.Keywords
This publication has 16 references indexed in Scilit:
- Human Nephropathy Related to Ochratoxin a in TunisiaJournal of Toxicology: Toxin Reviews, 1996
- Foodstuffs and human blood contamination by the mycotoxin ochratoxin A: correlation with chronic interstitial nephropathy in TunisiaArchives of Toxicology, 1995
- Ochratoxin A in human blood in relation to nephropathy in TunisiaHuman & Experimental Toxicology, 1995
- Determination of ochratoxin A at the ppt level in human blood, serum, milk and some foodstuffs by high-performance liquid chromatography with enhanced fluorescence detection and immunoaffinity column cleanup: methodology and Swiss dataJournal of Chromatography B: Biomedical Sciences and Applications, 1995
- Differential DNA adduct formation and disappearance in three mouse tissues after treatment with the mycotoxin ochratoxin AMutation Research, 1993
- A review of recent advances in understanding ochratoxicosisJournal of Animal Science, 1992
- Ochratoxin A: A review (Technical Report)Published by Walter de Gruyter GmbH ,1992
- Ochratoxin A in der NahrungsmittelketteJournal of Veterinary Medicine, Series B, 1987
- Genotoxicity of ochratoxin a in mice: DNA single-strand break evaluation in spleen, liver and kidneyToxicology Letters, 1985
- Ochratoxin A in human blood and Balkan endemic nephropathyArchives of Toxicology, 1982