Cutpoints for Muscle Mass and Strength Derived from Weakness or Mobility Impairment and Compared with Other Diagnostic Criteria in Community-Dwelling Elderly People
- 1 March 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Calcified Tissue International
- Vol. 108 (3), 324-345
- https://doi.org/10.1007/s00223-020-00778-0
Abstract
We identified the strength cutpoints concerning mobility impairment, then identified the muscle mass cutpoints concerning weakness, and compared the results with other diagnostic criteria to develop the clinical diagnostic criteria associated with functional impairment. In 7583 elderly people, classification and regression tree (CART) and receiver operating characteristic curve (ROC) analyses were used for determining cutpoints for handgrip strength (HGS) and appendicular lean mass (ALM) indices associated with slowness or weakness. Logistic regressions were then used to quantify the strength of the association between muscle mass (or strength) categories and weakness (or slowness). The CART second cutpoints of muscle mass and strength indices were lower than those specified by the ROC method and were between those cutpoints determined by the 20th and Mean-2SD methods. After adjusting for covariates, the associations remained significant in handgrip strength categories defined by the CART and ROC cutpoints and HGS/BMI categories defined by the CART, ROC, and 20th cutpoints in men and women (P < 0.05), ALM, ALM/Ht(2) categories defined by all four cutpoints (P < 0.05) and ALM/BMI categories defined by CART and ROC cutpoints in men (P < 0.05), and ALM and ALM/Ht(2) categories defined by the CART cutpoints in women (P < 0.05). Our approaches resulted in a definition of weak strength as handgrip strength or HGS/BMI less than 26.55 kg or 1.114 in men and less than 16.45 kg or 0.697 in women and then defined ALM, ALM/Ht(2), or ALM/BMI less than 18.92 kg, 7.08 kg/m(2), or 0.795 in men and less than 15.04 kg, 5.99 kg/m(2), or 0.517 in women as low lean mass.Funding Information
- National Key R&D Program of China (2017YFF0206601)
- National Basic Work in Science and Technology (2013FY110200)
This publication has 41 references indexed in Scilit:
- Sarcopenia in Asia: Consensus Report of the Asian Working Group for SarcopeniaJournal of the American Medical Directors Association, 2014
- A cross-sectional study of loss of muscle mass corresponding to sarcopenia in healthy Chinese men and women: reference values, prevalence, and association with bone massJournal of Bone and Mineral Metabolism, 2013
- Discrepancy Between the Quantitative Ultrasound Value of Malaysian Men and the Manufacturer’s Reference and the Impact on Classification of Bone Health StatusJournal of Clinical Densitometry, 2013
- Sarcopenia: An Undiagnosed Condition in Older Adults. Current Consensus Definition: Prevalence, Etiology, and Consequences. International Working Group on SarcopeniaJournal of the American Medical Directors Association, 2011
- Gait Speed and Survival in Older AdultsJAMA, 2011
- Simple equations to predict concentric lower-body muscle power in older adults using the 30-second chair-rise test: a pilot studyClinical Interventions in Aging, 2010
- Sarcopenia: European consensus on definition and diagnosisAge and Ageing, 2010
- Consumption of medium- and long-chain triacylglycerols decreases body fat and blood triglyceride in Chinese hypertriglyceridemic subjectsEuropean Journal of Clinical Nutrition, 2009
- Alternative Definitions of Sarcopenia, Lower Extremity Performance, and Functional Impairment with Aging in Older Men and WomenJournal of the American Geriatrics Society, 2007
- Knee Extension Strength Cutpoints for Maintaining MobilityJournal of the American Geriatrics Society, 2007