Effects of supplementation with curcuminoids on serum adipokines in critically ill patients: a randomized double‐blind placebo‐controlled trial
- 15 June 2020
- journal article
- research article
- Published by Wiley in Phytotherapy Research
- Vol. 34 (12), 3180-3188
- https://doi.org/10.1002/ptr.6749
Abstract
Previous studies have shown a beneficial effect of curcuminoids supplementation on serum concentrations of adipokines; however, there are no published studies that have examined this effect among critically ill patients. We aimed to assess the effects of supplementation with curcuminoids on serum concentrations of leptin and adiponectin in critically ill patients with traumatic brain injury (TBI). In this trial, 62 critically ill patients with TBI, aged 18–65 years, were randomly allocated to receive either 500 mg/day curcuminoids (co‐administered with 5 mg/day piperine) or matched placebo for 7 days. Patients in both intervention groups received routine treatments for TBI as well as enteral nutrition. Serum concentrations of leptin and adiponectin were measured at baseline and at the end of trial. We found a significant reduction in serum levels of leptin in both curcuminoids (47.1%) and placebo (22.8%) groups; though the magnitude of reduction was greater in the former (p < .05). Supplementation with curcumioinds was not found to alter serum concentrations of adiponectin (p > .05). Supplementation with curcumioinds significantly reduced serum levels of leptin but had no significant effect on adiponectin levels in critically ill patients with TBI. Further clinical trials, particularly those with a long‐term period, are needed to confirm our findings.Keywords
Funding Information
- Tehran University of Medical Sciences and Health Services (96–04–161‐37823)
This publication has 53 references indexed in Scilit:
- Trends in publication of evidence-based Traditional Iranian medicine in endocrinology and metabolic disordersJournal of Diabetes & Metabolic Disorders, 2013
- A systematic review of anti-obesity medicinal plants - an updateJournal of Diabetes & Metabolic Disorders, 2013
- Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer TreatmentMolecules, 2011
- Identifying critically ill patients who benefit the most from nutrition therapy: the development and initial validation of a novel risk assessment toolCritical Care, 2011
- Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other NutraceuticalsAnnual Review of Nutrition, 2010
- Relevance of Serum Leptin and Leptin-Receptor Concentrations in Critically Ill PatientsMediators of Inflammation, 2010
- Curcumin Supplementation Lowers TNF-α, IL-6, IL-8, and MCP-1 Secretion in High Glucose-Treated Cultured Monocytes and Blood Levels of TNF-α, IL-6, MCP-1, Glucose, and Glycosylated Hemoglobin in Diabetic RatsAntioxidants and Redox Signaling, 2009
- Adiponectin, retinol-binding protein 4, and leptin in protracted critical illness of pulmonary originCritical Care, 2009
- Changes in serum adiponectin concentrations in critical illness: a preliminary investigationCritical Care, 2009
- APACHE IICritical Care Medicine, 1985