Curcumin Supplementation Lowers TNF-α, IL-6, IL-8, and MCP-1 Secretion in High Glucose-Treated Cultured Monocytes and Blood Levels of TNF-α, IL-6, MCP-1, Glucose, and Glycosylated Hemoglobin in Diabetic Rats
- 1 February 2009
- journal article
- research article
- Published by Mary Ann Liebert Inc in Antioxidants and Redox Signaling
- Vol. 11 (2), 241-249
- https://doi.org/10.1089/ars.2008.2140
Abstract
This study examined the hypothesis that curcumin supplementation decreases blood levels of IL-6, MCP-1, TNF-α, hyperglycemia, and oxidative stress by using a cell-culture model and a diabetic rat model. U937 monocytes were cultured with control (7 mM) and high glucose (35 mM) in the absence or presence of curcumin (0.01–1 μM) at 37°C for 24 h. Diabetes was induced in Sprague–Dawley rats by injection of streptozotocin (STZ) (i.p., 65 mg/kg BW). Control buffer, olive oil, or curcumin (100 mg/kg BW) supplementation was administered by gavage daily for 7 weeks. Blood was collected by heart puncture with light anesthesia. Results show that the effect of high glucose on lipid peroxidation, IL-6, IL-8, MCP-1, and TNF-α secretion was inhibited by curcumin in cultured monocytes. In the rat model, diabetes caused a significant increase in blood levels of IL-6, MCP-1, TNF-α, glucose, HbA1, and oxidative stress, which was significantly decreased in curcumin-supplemented rats. Thus, curcumin can decrease markers of vascular inflammation and oxidative stress levels in both a cell-culture model and in the blood of diabetic rats. This suggests that curcumin supplementation can reduce glycemia and the risk of vascular inflammation in diabetes. Antioxid. Redox Signal. 11, 241–249.Keywords
This publication has 66 references indexed in Scilit:
- Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's DiseaseJournal of Pharmacology and Experimental Therapeutics, 2008
- Promoter Elements Responsible for Antioxidant Regulation of MCP-1 Gene ExpressionAntioxidants and Redox Signaling, 2007
- Oxidative Stress, Glucose Metabolism, and the Prevention of Type 2 Diabetes: Pathophysiological InsightsAntioxidants and Redox Signaling, 2007
- Effects of curcumin on retinal oxidative stress and inflammation in diabetesNutrition & Metabolism, 2007
- CURCUMIN: THE INDIAN SOLID GOLDAdvances in experimental medicine and biology, 2006
- Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1Oncogene, 2005
- The Molecular Basis for Oxidative Stress-Induced Insulin ResistanceAntioxidants and Redox Signaling, 2005
- Diabetic ketoacidosis, hyperosmolarity and hypernatremia: are high-carbohydrate drinks worsening initial presentation?Pediatric Diabetes, 2005
- Activation of PPARγ by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFRAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2005
- Molecular Mechanisms Mediating Inflammation in Vascular DiseaseHypertension, 2003