Brainstem neurons that command mammalian locomotor asymmetries
- 1 June 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Neuroscience
- Vol. 23 (6), 730-+
- https://doi.org/10.1038/s41593-020-0633-7
Abstract
Descending command neurons instruct spinal networks to execute basic locomotor functions, such as gait and speed. The command functions for gait and speed are symmetric, implying that a separate unknown system directs asymmetric movements, including the ability to move left or right. In the present study, we report that Chx10-lineage reticulospinal neurons act to control the direction of locomotor movements in mammals. Chx10 neurons exhibit mainly ipsilateral projection, and their selective unilateral activation causes ipsilateral turning movements in freely moving mice. Unilateral inhibition of Chx10 neurons causes contralateral turning movements. Paired left-right motor recordings identified distinct mechanisms for directional movements mediated via limb and axial spinal circuits. Finally, we identify sensorimotor brain regions that project on to Chx10 reticulospinal neurons, and demonstrate that their unilateral activation can impart left-right directional commands. Together these data identify the descending motor system that commands left-right locomotor asymmetries in mammals. Cregg et al. find that a specific population of brainstem neurons act to control left-right turning of locomotor movements in mammals through distinct axial- and limb-based mechanisms. This turning pathway is the dominant system for natural directional movements.This publication has 60 references indexed in Scilit:
- Spinal Projection Neurons Control Turning Behaviors in ZebrafishCurrent Biology, 2013
- Spinal and Supraspinal Control of the Direction of Stepping during LocomotionJournal of Neuroscience, 2012
- Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memoryNature Neuroscience, 2011
- A transgenic mouse line for molecular genetic analysis of excitatory glutamatergic neuronsMolecular and Cellular Neuroscience, 2010
- Monosynaptic circuit tracing in vivo through Cre-dependent targeting and complementation of modified rabies virusProceedings of the National Academy of Sciences of the United States of America, 2010
- Glycinergic Projection Neurons of the CerebellumJournal of Neuroscience, 2009
- Circuits controlling vertebrate locomotion: moving in a new directionNature Reviews Neuroscience, 2009
- Neural Substrates of Sensory-Guided Locomotor Decisions in the Rat Superior ColliculusNeuron, 2008
- Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligandProceedings of the National Academy of Sciences of the United States of America, 2007
- Genome-wide atlas of gene expression in the adult mouse brainNature, 2006