Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory
- 30 January 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Neuroscience
- Vol. 14 (3), 297-299
- https://doi.org/10.1038/nn.2751
Abstract
Disruption of the hippocampus influences both spatial reference and working memory. By selectively blocking parvalbumin-positive interneuron signaling, the authors find that this class of neurons contributes to spatial working memory, but not to reference memory. Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.Keywords
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