Enhancing the biological activity of polyoxometalate–peptide nano-fibrils by spacer design
Open Access
- 26 January 2021
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in RSC Advances
- Vol. 11 (9), 4952-4957
- https://doi.org/10.1039/d0ra10218k
Abstract
Polyoxometalates (POMs) and peptides can be conjugated to yield novel bio-hybrids with potential application as nanodrugs. However, the observed POM-induced folding of the peptide prevents its availability towards biological targets. An Anderson–Evans POM was functionalized with a bombesin analog peptide and engineered by adding a tailored hydrophilic and anionic spacer between the two moieties, to make the targeting sequence more accessible and enable an unprecedented cancer cell recognition capability.Keywords
Funding Information
- Università degli Studi di Padova (P-DiSC #11NExuS_BIRD2019-UNIPD)
- Ministero dell'Istruzione, dell'Università e della Ricerca (PRIN Nanoredox, Prot. 2017PBXPN4)
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