Cellular and molecular imaging for stem cell tracking in neurological diseases
Open Access
- 29 October 2020
- journal article
- review article
- Published by BMJ in Stroke and Vascular Neurology
- Vol. 6 (1), 121-127
- https://doi.org/10.1136/svn-2020-000408
Abstract
Stem cells (SCs) are cells with strong proliferation ability, multilineage differentiation potential and self-renewal capacity. SC transplantation represents an important therapeutic advancement for the treatment strategy of neurological diseases, both in the preclinical experimental and clinical settings. Innovative and breakthrough SC labelling and tracking technologies are widely used to monitor the distribution and viability of transplanted cells non-invasively and longitudinally. Here we summarised the research progress of the main tracers, labelling methods and imaging technologies involved in current SC tracking technologies for various neurological diseases. Finally, the applications, challenges and unresolved problems of current SC tracing technologies were discussed.Keywords
Funding Information
- National Science Foundation of China (81801199, 81830038, 81971094, 91949208)
- Beijing Municipal Science & Technology Commission (Z181100001818001)
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