Non-Islet Cell Tumor Hypoglycemia Caused by Recurrent Pelvic Solitary Fibrous Tumor
Open Access
- 23 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Cureus
- Vol. 13 (1)
- https://doi.org/10.7759/cureus.12878
Abstract
Non-islet cell tumor hypoglycemia is a rare paraneoplastic condition caused by an extra-pancreatic tumor. We report a rare case of hypoglycemia caused by a relapsing pelvic solitary fibrous tumor associated with Big-IGF-2 production. A 72-year-old woman was admitted to our hospital because of loss of consciousness and hypoglycemia. She had a history of ovarian solitary fibrous tumor, which has relapsed. From investigation, serum levels of insulin and C-peptide were suppressed; IGF-1 was slightly reduced and IGF-2 was within the normal range, but the IGF-2: IGF-1 ratio was elevated, indicating the presence of Big-IGF-2 secreting non-islet cell tumor. Contrast-enhanced computed tomography (CT) showed a large pelvic mass. She was then submitted to surgical resection of the mass, which histologically proved to he a solitary fibrous tumor. Three months later, she remains asymptomatic. Non-islet cell tumor hypoglycemia should be considered in the differential diagnosis of patients presenting with tumors and recurrent hypoglycemia.This publication has 17 references indexed in Scilit:
- Late recurrence of a malignant hypoglycemia-inducing pelvic solitary fibrous tumor secreting high-molecular-weight insulin-like growth factor-II: A case report with protein analysisOncology Letters, 2016
- Non-islet cell tumor hypoglycemia caused by intrathoracic solitary fibrous tumor: a case report.Journal of Cardiothoracic Surgery, 2016
- Spontaneous hypoglycemia: diagnostic evaluation and managementEndocrine, 2016
- Hypoglycemia Associated with a Gastrointestinal Stromal Tumor Producing High-molecular-weight Insulin Growth Factor II: A Case Report and Literature ReviewInternal Medicine, 2016
- Doege–Potter SyndromeThe Annals of The Royal College of Surgeons of England, 2015
- Hypoglycemia mediated by paraneoplastic production of Insulin like growth factor–2 from a malignant renal solitary fibrous tumor – clinical case and literature reviewBMC Endocrine Disorders, 2014
- IGF-II-secreting pelvic tumor presenting with neuropsychiatric symptomsJournal of Surgical Case Reports, 2013
- A rare case of hypoglycemia in a patient with elevated right hemidiaphragmBMJ Case Reports, 2012
- Recurrent Solitary Fibrous Tumor of the Pleura with Malignant Transformation and Non-islet Cell Tumor-induced Hypoglycemia due to Paraneoplastic Overexpression and Secretion of High-molecular-weight Insulin-like Growth Factor IIInternal Medicine, 2012
- Retroperitoneal Solitary Fibrous Tumor-Induced Hypoglycemia Associated with High Molecular Weight Insulin-Like Growth Factor IIClinical Medicine & Research, 2010