A rare case of hypoglycemia in a patient with elevated right hemidiaphragm
- 28 June 2012
- journal article
- case report
- Published by BMJ in Case Reports
- Vol. 2012 (jun28 1)
- https://doi.org/10.1136/bcr.03.2012.5972
Abstract
A 57-year-old woman was admitted to the emergency department, presenting with episodes of altered consciousness and behaviour which, upon further examination, were linked to periods of recurrent hypoglycaemia. Imaging revealed a large mass in the right thoracic cavity while blood analysis demonstrated diminished C-peptide, (pro-)insulin, insulin-like growth factor 1 (IGF-I) and IGF binding protein 3 levels. Based on these findings, an IGF-II secreting tumour was suspected. Before the excision of the tumour, euglycaemia could only be achieved by means of intravenous glucose administration and the use of oral corticosteroids. Anatomopathologically the diagnosis of a solitary fibrous tumour (SFT) was confirmed. Immunoblot analysis on the serum revealed elevated ‘big’-IGF-II levels, confirming our initial diagnosis of Doege–Potter syndrome in SFT.Keywords
This publication has 9 references indexed in Scilit:
- Surgically cured hypoglycemia secondary to pleural solitary fibrous tumour: case report and update review on the Doege-Potter syndromeJournal of Cardiothoracic Surgery, 2009
- Non-islet cell tumour-induced hypoglycaemia: a review of the literature including two new casesEndocrine-Related Cancer, 2007
- Fine needle aspiration cytology of solitary fibrous tumours of the pleuraCytopathology, 2007
- Clinical features of insulin-like growth factor-II producing non-islet-cell tumor hypoglycemiaGrowth Hormone & IGF Research, 2006
- The effectiveness of different treatment options for non‐islet cell tumour hypoglycaemiaClinical Endocrinology, 2004
- Antibodies Directed against the E Region of Pro-Insulin-like Growth Factor-II Used to Evaluate Non-Islet Cell Tumor-induced HypoglycemiaClinical Chemistry, 2002
- Transthoracic fine-needle aspiration biopsy of pulmonary spindle cell and mesenchymal lesionsCancer, 2001
- Solitary fibrous tumors of the pleura: Eight new cases and review of 360 cases in the literatureCancer, 1981
- Hypoglycemia Associated with Fibrosarcoma of MediastinumAnnals of Surgery, 1964