Retroperitoneal Solitary Fibrous Tumor-Induced Hypoglycemia Associated with High Molecular Weight Insulin-Like Growth Factor II
- 17 September 2010
- journal article
- case report
- Published by Marshfield Clinic Research Institute in Clinical Medicine & Research
- Vol. 8 (3-4), 159-162
- https://doi.org/10.3121/cmr.2010.888
Abstract
A man, aged 65 years, presented with frequent episodes of hypoglycemia and unconsciousness. Hypoglycemia was accompanied by undetectable serum insulin and C-peptide levels and a high serum insulin-like growth factor (IGF)-II level. He was found to have a retroperitoneal solitary fibrous tumor. He underwent successful resection of the tumor and had no hypoglycemic episodes after the operation. Immunohistochemical analysis revealed positive immunostaining for IGF-II in tumor cells. The presence of the high-molecular-weight form of IGF-II in the patient’s serum was confirmed by immunoblotting, which suggests that his hypoglycemia was due to an increase in the plasma level of IGF-II secreted by the tumor.Keywords
This publication has 16 references indexed in Scilit:
- [A case of retroperitoneal solitary fibrous tumor associated with hypoglycemia].2009
- Hypoglycemia Associated with Big Insulin-Like Growth Factor II Produced during Development of Malignant Fibrous HistiocytomaEndocrine Journal, 2003
- Extrathoracic solitary fibrous tumors: Their histological variability and potentially aggressive behaviorHuman Pathology, 1999
- Serum High Molecular Weight Form of Insulin-Like Growth Factor II from Patients with Non-Islet Cell Tumor Hypoglycemia Is O-Glycosylated1Journal of Clinical Endocrinology & Metabolism, 1998
- Solitary fibrous tumour: clinicopathological, immunohistochemical, and ultrastructural analysis of 12 cases arising in soft tissues, nasal cavity and nasopharynx, urinary bladder and prostateVirchows Archiv, 1997
- Solitary Fibrous Tumor of the Upper Respiratory TractThe American Journal of Surgical Pathology, 1991
- Solitary Fibrous Tumor of the Nasal Cavity and Paranasal SinusesThe American Journal of Surgical Pathology, 1991
- Localized Benign and Malignant Fibrous Tumors of the PleuraThe American Journal of Surgical Pathology, 1989
- Increased Insulin-Like Growth Factor II Production and Consequent Suppression of Growth Hormone Secretion: A Dual Mechanism for Tumor-Induced HypoglycemiaJournal of Clinical Endocrinology & Metabolism, 1989
- Solitary fibrous tumors of the pleura: Eight new cases and review of 360 cases in the literatureCancer, 1981