Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties
- 22 December 2011
- journal article
- Published by Institute of Organic Chemistry & Biochemistry in Collection of Czechoslovak Chemical Communications
- Vol. 76 (12), 1549-1566
- https://doi.org/10.1135/cccc2011152
Abstract
We report on the preparation of novel 1′-homonucleoside derivatives locked in a West conformation by 1′,4′-bridge consisting of annulated benzene or naphthalene ring. The crucial step of the synthesis was Diels–Alder reaction of an appropriate aryne with a suitable furane derivative. Antiviral properties of novel compounds were studied and slight activity against HCV was detected in several compounds.Keywords
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