Synthesis and Biological Activity of Phosphonated Nucleosides: Part 1Furanose, Carbocyclic and Heterocyclic Analogues

Abstract

Phosphonated nucleosides represent a promising alternative in the improvement of the biological activity of nucleoside analogues in antiviral and anticancer chemotherapy. The basic concept, the chemistry, the different structural modifications and their effects on the antiviral potency will be discussed in this review.