NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines
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Open Access
- 27 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Communications
- Vol. 12 (1), 1-7
- https://doi.org/10.1038/s41467-020-20888-5
Abstract
Enantiomerically pure chiral amines and related amide derivatives are privilege motifs in many pharmacologically active molecules. In comparison to the well-established hydroamination, the transition metal-catalysed asymmetric hydrofunctionalization of enamines provides a complementary approach for their construction. Here we report a NiH-catalysed enantio- and regioselective reductive hydroarylation of N-acyl enamines, allowing for the practical access to a broad range of structurally diverse, enantioenriched benzylamines under mild, operationally simple reaction conditions.Funding Information
- National Natural Science Foundation of China (21822105, 21772087, 22001118)
- Natural Science Foundation of Jiangsu Province (BK20200300)
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