Copper Hydride Catalyzed Hydroamination of Alkenes and Alkynes
Top Cited Papers
Open Access
- 10 December 2015
- journal article
- review article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 55 (1), 48-57
- https://doi.org/10.1002/anie.201507594
Abstract
Over the past few years, CuH‐catalyzed hydroamination has been discovered and developed as a robust and conceptually novel approach for the synthesis of enantioenriched secondary and tertiary amines. The success in this area of research was made possible through the large body of precedent in copper(I) hydride catalysis and the well‐explored use of hydroxylamine esters as electrophilic amine sources in related copper‐catalyzed processes. This Minireview details the background, advances, and mechanistic investigations in CuH‐catalyzed hydroamination.Keywords
Funding Information
- National Institutes of Health (GM58160, GM113311, GM112218)
This publication has 103 references indexed in Scilit:
- Enantioselective Thiourea-Catalyzed Intramolecular Cope-Type HydroaminationJournal of the American Chemical Society, 2013
- Copper‐Catalyzed Amination of Ketene Silyl Acetals with Hydroxylamines: Electrophilic Amination Approach to α‐Amino AcidsAngewandte Chemie-International Edition, 2012
- Organosilicon Molecules with Medicinal ApplicationsJournal of Medicinal Chemistry, 2012
- Copper‐Catalyzed Amination of Arylboronates with N,N‐DialkylhydroxylaminesAngewandte Chemie-International Edition, 2012
- Copper‐Catalyzed Amination of Arylboronates with N,N‐DialkylhydroxylaminesAngewandte Chemie, 2012
- Asymmetric additions to dienes catalysed by a dithiophosphoric acidNature, 2011
- The enantioselective intramolecular aminative functionalization of unactivated alkenes, dienes, allenes and alkynes for the synthesis of chiral nitrogen heterocyclesOrganic & Biomolecular Chemistry, 2009
- Intermolecular Cope-Type Hydroamination of Alkenes and AlkynesAngewandte Chemie, 2008
- Base-Catalyzed Hydroamination of Olefins: An Environmentally Friendly Route to AminesAdvanced Synthesis & Catalysis, 2002
- Effect of Copper (I) Iodide and Magnesium Chloride on Amination of Aryl Grignards with KetoximesSynthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, 1989