New Strategies for the Transition-Metal Catalyzed Synthesis of Aliphatic Amines
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Open Access
- 17 February 2020
- journal article
- review article
- Published by American Chemical Society (ACS) in Chemical Reviews
- Vol. 120 (5), 2613-2692
- https://doi.org/10.1021/acs.chemrev.9b00462
Abstract
Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from simple, readily available feedstocks have become a cornerstone of modern synthetic organic chemistry. In light of the ever-increasing importance of aliphatic amines across the range of chemical sciences, this review aims to provide a concise overview of modern transition-metal catalyzed approaches to alkylamine synthesis and their functionalization. Selected examples of amine bond forming reactions include: (a) hydroamination and hydroaminoalkylation, (b) transition-metal catalyzed C(sp3)–H functionalization, and (c) transition-metal catalyzed visible-light-mediated light photoredox catalysis.Keywords
Funding Information
- AstraZeneca
- Royal Society
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