Allostatic Load in Women With and Without PTSD Symptoms
- 1 June 2006
- journal article
- Published by Guilford Publications in Psychiatry: Interpersonal & Biological Processes
- Vol. 69 (3), 191-203
- https://doi.org/10.1521/psyc.2006.69.3.191
Abstract
Allostatic load (AL) is the term used to describe cumulative physiological wear and tear that results from repeated efforts to adapt to stressors over time. Operationalized as a composite index of biological risk factors (e.g., blood pressure, cholesterol, glycosylated hemoglobin, and cortisol, norepinephrine, and epinephrine), AL has been shown to increase with age, predict long–term morbidity and mortality among the elderly, and be associated with low parent education in a large adolescent sample. However, AL has not yet been studied in samples with putative “high stress” or posttraumatic stress disorder (PTSD). Accordingly, AL was measured in women with high acute and chronic stress: mothers of pediatric cancer survivors with and without PTSD and control mothers of healthy children. AL emerged in a “dose–dependent” ranking from high to low: cancer mothers meeting all criteria for PTSD, cancer mothers with no or low symptoms, and control mothers, respectively (p < .001). Effects were not altered by self–reported sleep quality or substance use (tobacco, caffeine, alcohol, or drugs) and remained significant when analyzing AL without cortisol or catecholamines. Results indicate elevated AL can be detected in relatively young women with high stress histories and particularly those with PTSD. Future prospective studies must evaluate whether this pattern represents an accelerated aging process and increased risk of disease.Keywords
This publication has 53 references indexed in Scilit:
- Systematic review of screening instruments for adults at risk of PTSDJournal of Traumatic Stress, 2005
- Social Inequalities in Biomarkers of Cardiovascular Risk in AdolescencePsychosomatic Medicine, 2005
- The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and diseaseNeuroscience & Biobehavioral Reviews, 2004
- Allostatic Load, Perceived Stress, and Health: A Prospective Study in Two Age GroupsAnnals of the New York Academy of Sciences, 2004
- Protection and Damage from Acute and Chronic Stress: Allostasis and Allostatic Overload and Relevance to the Pathophysiology of Psychiatric DisordersAnnals of the New York Academy of Sciences, 2004
- Further Lessons from 9/11: Does Stress Equal Trauma?Psychiatry: Interpersonal & Biological Processes, 2004
- Opposite Turning Behavior in Right-Handers and Non-Right-Handers Suggests a Link Between Handedness and Cerebral Dopamine Asymmetries.Behavioral Neuroscience, 2003
- Allostatic load as a predictor of functional declineJournal of Clinical Epidemiology, 2002
- Substance Use Disorders in Patients With Posttraumatic Stress Disorder: A Review of the LiteratureAmerican Journal of Psychiatry, 2001
- Posttraumatic stress, family functioning, and social support in survivors of childhood leukemia and their mothers and fathers.Journal of Consulting and Clinical Psychology, 1997