ELM--the database of eukaryotic linear motifs
Open Access
- 21 November 2011
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 40 (D1), D242-D251
- https://doi.org/10.1093/nar/gkr1064
Abstract
Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide low-affinity interaction interfaces. These compact modules play central roles in mediating every aspect of the regulatory functionality of the cell. They are particularly prominent in mediating cell signaling, controlling protein turnover and directing protein localization. Given their importance, our understanding of motifs is surprisingly limited, largely as a result of the difficulty of discovery, both experimentally and computationally. The Eukaryotic Linear Motif (ELM) resource at http://elm.eu.org provides the biological community with a comprehensive database of known experimentally validated motifs, and an exploratory tool to discover putative linear motifs in user-submitted protein sequences. The current update of the ELM database comprises 1800 annotated motif instances representing 170 distinct functional classes, including approximately 500 novel instances and 24 novel classes. Several older motif class entries have been also revisited, improving annotation and adding novel instances. Furthermore, addition of full-text search capabilities, an enhanced interface and simplified batch download has improved the overall accessibility of the ELM data. The motif discovery portion of the ELM resource has added conservation, and structural attributes have been incorporated to aid users to discriminate biologically relevant motifs from stochastically occurring non-functional instances.Keywords
This publication has 42 references indexed in Scilit:
- Sorting the nuclear proteomeBioinformatics, 2011
- The multiple‐specificity landscape of modular peptide recognition domainsMolecular Systems Biology, 2011
- Phospho.ELM: a database of phosphorylation sites--update 2011Nucleic Acids Research, 2010
- Y65C Missense Mutation in the WW Domain of the Golabi-Ito-Hall Syndrome Protein PQBP1 Affects Its Binding Activity and Deregulates Pre-mRNA SplicingOnline Journal of Public Health Informatics, 2010
- ELM: the status of the 2010 eukaryotic linear motif resourceNucleic Acids Research, 2009
- Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hairNature Genetics, 2009
- Minimotif miner 2nd release: a database and web system for motif searchNucleic Acids Research, 2008
- SMART 6: recent updates and new developmentsNucleic Acids Research, 2008
- The 20 years of PROSITENucleic Acids Research, 2007
- IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy contentBioinformatics, 2005