Altered Map of Visual Space in the Superior Colliculus of Mice Lacking Early Retinal Waves
Open Access
- 20 July 2005
- journal article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 25 (29), 6921-6928
- https://doi.org/10.1523/jneurosci.1555-05.2005
Abstract
During the development of the mammalian retinocollicular projection, a coarse retinotopic map is set up by the graded distribution of axon guidance molecules. Subsequent refinement of the initially diffuse projection has been shown to depend on the spatially correlated firing of retinal ganglion cells. In this scheme, the abolition of patterned retinal activity is not expected to influence overall retinotopic organization, but this has not been investigated. We used optical imaging of intrinsic signals to visualize the complete retinotopic map in the superior colliculus (SC) of mice lacking early retinal waves, caused by the deletion of the β2 subunit of the nicotinic acetylcholine receptor. As expected from previous anatomical studies in the SC of β2-/-mice, regions activated by individual visual stimuli were much larger and had less sharp borders than those in wild-type mice. Importantly, however, we also found systematic distortions of the entire retinotopic map: the map of visual space was expanded anteriorly and compressed posteriorly. Thus, patterned neuronal activity in the early retina has a substantial influence on the coarse retinotopic organization of the SC.Keywords
This publication has 45 references indexed in Scilit:
- Evidence for an Instructive Role of Retinal Activity in Retinotopic Map Refinement in the Superior Colliculus of the MouseJournal of Neuroscience, 2005
- The role of nAChR‐mediated spontaneous retinal activity in visual system developmentJournal of Neurobiology, 2002
- Retinal Waves: Implications for Synaptic Learning Rules during DevelopmentThe Neuroscientist, 2002
- Early functional neural networks in the developing retinaNature, 1995
- Pre- and postnatal development of high-affinity [3H]nicotine binding sites in rat brain regions: an autoradiographic studyDevelopmental Brain Research, 1992
- NMDA receptor antagonists disrupt the retinotectal topographic mapNeuron, 1989
- Effects of intraocular tetrodotoxin on the development of the retinocollicular pathway in the syrian hamsterJournal of Comparative Neurology, 1989
- Spontaneous Impulse Activity of Rat Retinal Ganglion Cells in Prenatal LifeScience, 1988
- Functional architecture of cortex revealed by optical imaging of intrinsic signalsNature, 1986
- How patterned neural connections can be set up by self-organizationProceedings of the Royal Society of London. B. Biological Sciences, 1976