Congenital Penile Pathology is Associated with Abnormal Development of the Dartos Muscle: A Prospective Study of Primary Penile Surgery at a Tertiary Referral Center
- 1 May 2015
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Urology
- Vol. 193 (5), 1620-1624
- https://doi.org/10.1016/j.juro.2014.10.090
Abstract
Pathophysiological mechanisms leading to chordee in patients with hypospadias and to the hidden state of buried penis in the prepubic fat remain unclear. Resection of dartos tissue usually makes the penis straight in patients with hypospadias and corrects it in those with buried penis, suggesting a common pathophysiology related to dartos tissue.Tissue samples from 113 children undergoing primary penile surgery for hypospadias (94 patients), epispadias (1) or buried penis (18) were collected between November 2011 and September 2013. Tissue samples from 79 children undergoing circumcision for nonmedical reasons served as controls. All samples were stained with smooth muscle actin and analyzed by the same pathologist, who was blinded to indication for surgery. Chi-square and Fisher exact tests were applied.Three different dartos tissue patterns were observed. Pattern I (normal) consisted of smooth muscle fibers of dartos tissue organized in a parallel configuration in the subcutaneous tissue. Pattern II was characterized by poorly developed and hypotrophic smooth muscle fibers. Pattern III was determined by randomly distributed smooth muscle fibers in the subcutaneous tissue, without parallel configuration. Pattern I was observed in 45 circumcision specimens (64%). Of buried penis cases 78% were considered abnormal (pattern II in 4 cases and III in 10, p = 0.001). Of hypospadias cases 70% were considered abnormal (pattern II in 31 cases, III in 32, and mixed II and III in 3, p < 0.001). The only epispadias case was designated pattern II.Congenital penile pathology (hypospadias, buried penis) is associated with structural anomalies in dartos tissue. Further research is needed to unveil the pathophysiology of the condition.Keywords
This publication has 25 references indexed in Scilit:
- New Surgical Technique for the Treatment of Buried Penis: Results and Comparison with a Traditional Technique in 75 PatientsUrologia Internationalis, 2013
- Hypospadias Repair: An Overview of the Actual TechniquesSeminars in Plastic Surgery, 2011
- Hypospadias dilemmas: A round tableJournal of Pediatric Urology, 2011
- Secular trends of hypospadias prevalence and factors associated with it in southeast China during 1993–2005Birth Defects Research Part A: Clinical and Molecular Teratology, 2010
- A Farewell to ChordeeJournal of Urology, 2007
- BURIED PENIS: CONGENITAL SYNDROME OF A SHORT PENILE SHAFT AND A PAUCITY OF PENILE SHAFT SKINJournal of Urology, 2005
- THE USE OF FREE GRAFTS FOR CORRECTING PENILE CHORDEEJournal of Urology, 2000
- HISTOLOGY OF THE URETHRAL PLATE: IMPLICATIONS FOR HYPOSPADIAS REPAIRJournal of Urology, 2000
- Penile curvatureUrology, 1996
- Injection technique to induce penile erectionUrology, 1974