Joint Symptoms, Aromatase Inhibitor-Related Adverse Reactions, Are Indirectly Associated with Decreased Serum Estradiol
Open Access
- 26 May 2011
- journal article
- research article
- Published by Hindawi Limited in International Journal of Surgical Oncology
- Vol. 2011, 1-7
- https://doi.org/10.1155/2011/951260
Abstract
Background. Joint symptoms (JSs) are problematic adverse drug reactions (ADRs) of aromatase inhibitors (AIs). Involvement of decreased serum estradiol (SE) has been suggested.Patients and Methods. 104 postmenopausal breast cancer patients administered an AI were prospectively investigated regarding various clinical parameters, JS and hot flashes as ADRs, and the SE level.Results. JS manifested in 31.7% of patients and hot flashes in 18.3%. Chi-square testing showed a significantly higher incidence of JS in several patient strata: 6 consecutive months, with no JS. In chi-square testing, hot flashes showed a significantly higher incidence in patients Conclusion. AI-ADRs occurred more readily in younger patients. Decreased SE may be indirectly involved in JS.Keywords
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