The Influence of Exercise on Metabolic Syndrome in Youth: A Review

Abstract

The metabolic syndrome (MetS) is a clustering of dyslipidemia, hypertension, glucose intolerance, and central obesity or waist circumference that places individuals at high risk for developing cardiovascular or heart disease. Although first characterized in adults, it has been found in children, but the definition of MetS in children is still controversial. Although MetS is most closely associated with obesity in children, 2 factors believed to affect MetS are physical activity (PA) and aerobic power or fitness. Studies using accelerometry to estimate PA of children have shown that low levels are associated with increased risk of developing MetS. Conversely, high levels of PA at moderate to vigorous intensities reduce the risk. Similarly, low levels of aerobic fitness increase the likelihood of developing MetS. These effects appear to be independent of obesity. Studies have also shown that interventions that increase PA levels and improve aerobic fitness cause a reduction in MetS risk; however, an exact prescription for exercise cannot be presently provided. This review provides an in-depth analysis of what is presently known about the relationship between MetS and PA and aerobic fitness in children. In addition, information is presented regarding potential mechanisms for exercise to affect the major markers of MetS.