Multivariate analysis of immunohistochemical evaluation of protein expression in pancreatic ductal adenocarcinoma reveals prognostic significance for persistent Smad4 expression only
Open Access
- 18 February 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Cellular Oncology
- Vol. 35 (2), 119-126
- https://doi.org/10.1007/s13402-012-0072-x
Abstract
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis with a 5-year survival rate of <5% and an average survival of only 6 months. Although advances have been made in understanding the pathogenesis of PDAC in the last decades, overall survival has not changed. Various clinicopathological and immunohistological variables have been associated with survival time but the exact role that these variables play in relation to survival is not clear.Keywords
This publication has 27 references indexed in Scilit:
- The Influence of Total Nodes Examined, Number of Positive Nodes, and Lymph Node Ratio on Survival After Surgical Resection and Adjuvant Chemoradiation for Pancreatic Cancer: A Secondary Analysis of RTOG 9704International Journal of Radiation Oncology*Biology*Physics, 2011
- Molecular pathogenesis of pancreatic cancerBest Practice & Research Clinical Gastroenterology, 2006
- DNA MISMATCH REPAIRAnnual Review of Biochemistry, 2005
- Pancreatic Cancer: Basic and Clinical AspectsGastroenterology, 2005
- Defective DNA mismatch repair in long-term (≥ 3 years) survivors with pancreatic cancerPancreatology, 2005
- Multicomponent Analysis of the Pancreatic Adenocarcinoma Progression Model Using a Pancreatic Intraepithelial Neoplasia Tissue MicroarrayLaboratory Investigation, 2003
- Immunohistochemical Labeling for Dpc4 Mirrors Genetic Status in Pancreatic Adenocarcinomas: A New Marker of DPC4 InactivationThe American Journal of Pathology, 2000
- Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumoursBritish Journal of Cancer, 1999
- Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+.1998
- DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1Science, 1996