The importance of butyrate transport to the regulation of gene expression in the colonic epithelium
- 26 October 2004
- journal article
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 32 (6), 1100-1102
- https://doi.org/10.1042/bst0321100
Abstract
Butyrate is a naturally occurring monocarboxylate, produced in the lumen of the colon by microbial fermentation of complex carbohydrates that escape digestion in the small intestine. It serves as the principal metabolic fuel for colonic epithelial cells, and exerts a variety of effects important to intestinal health and function. This brief discussion focuses on the route, role and regulation of butyrate transport in the large intestine, with particular emphasis on the significance of butyrate transport to the ability of butyrate to modulate expression of genes important to the processes maintaining colonic tissue homoeostasis.This publication has 27 references indexed in Scilit:
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