Potential for improvement of docetaxel-based chemotherapy: a pharmacological review
Open Access
- 12 July 2005
- journal article
- review article
- Published by Springer Science and Business Media LLC in British Journal of Cancer
- Vol. 93 (2), 173-177
- https://doi.org/10.1038/sj.bjc.6602698
Abstract
Since the introduction of docetaxel, research has focused on various approaches to overcome treatment limitations and improve outcome. This review discusses the pharmacological attempts at treatment optimisation, which include reducing interindividual pharmacokinetic and pharmacodynamic variability, optimising schedule, route of administration, reversing drug resistance and the development of structurally related second-generation taxanes.Keywords
This publication has 28 references indexed in Scilit:
- Docetaxel administration schedule: From fever to tears? A review of randomised studiesEuropean Journal Of Cancer, 2005
- Prospective Evaluation of the Pharmacokinetics and Toxicity Profile of Docetaxel in the ElderlyJournal of Clinical Oncology, 2005
- Randomized Pharmacokinetic and Pharmacodynamic Study of Docetaxel: Dosing Based on Body-Surface Area Compared With Individualized Dosing Based on Cytochrome P450 Activity Estimated Using a Urinary Metabolite of Exogenous CortisolJournal of Clinical Oncology, 2005
- Phase I Study of Docetaxel in Combination with the P-Glycoprotein Inhibitor, Zosuquidar, in Resistant MalignanciesClinical Cancer Research, 2004
- Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoproteinEuropean Journal Of Cancer, 2004
- Factors affecting pharmacokinetic variability following doxorubicin and docetaxel-based therapyEuropean Journal Of Cancer, 2004
- Docetaxel and ketoconazole in advanced hormone‐refractory prostate carcinomaCancer, 2003
- Docetaxel (Taxotere) Is Not Metabolized by Recombinant Human CYP1B1 in Vitro, but Acts as an Effector of This Isozyme.Drug Metabolism and Disposition, 2002
- Explaining Interindividual Variability of Docetaxel Pharmacokinetics and Pharmacodynamics in Asians Through Phenotyping and Genotyping StrategiesJournal of Clinical Oncology, 2002
- Cytochrome P450 CYP1B1 protein expression:Biochemical Pharmacology, 2001