Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus
Open Access
- 15 June 2010
- journal article
- review article
- Published by Hindawi Limited in Mediators of Inflammation
- Vol. 2010, 1-15
- https://doi.org/10.1155/2010/792393
Abstract
Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabetes related complications. This review summarizes the mechanisms by which the interplay between endothelial dysfunction, inflammation, and apoptosis may cause (micro)vascular damage in patients with diabetes mellitus.Keywords
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