Wound Healing Potential of Formulated Extract from Hibiscus Sabdariffa Calyx
Open Access
- 1 January 2013
- journal article
- research article
- Published by OMICS Publishing Group in Indian Journal of Pharmaceutical Sciences
- Vol. 75 (1), 45-52
- https://doi.org/10.4103/0250-474x.113549
Abstract
Wound healing agents support the natural healing process, reduce trauma and likelihood of secondary infections and hasten wound closure. The wound healing activities of water in oil cream of the methanol extract of Hibiscus sabdariffa L. (Malvaceae) was evaluated in rats with superficial skin excision wounds. Antibacterial activities against Pseudomonas aeroginosa, Staphylococcus aureus and Echerichia coli were determined. The total flavonoid content, antioxidant properties and thin layer chromatographic fingerprints of the extract were also evaluated. The extract demonstrated antioxidant properties with a total flavonoid content of 12.30±0.09 mg/g. Six reproducible spots were obtained using methanol:water (95:5) as the mobile phase. The extract showed no antimicrobial activity on the selected microorganisms, which are known to infect and retard wound healing. Creams containing H. sabdariffa extract showed significant (PH. sabdariffa extract. This study, thus, provides evidence of the wound healing potentials of the formulated extract of the calyces of H. sabdariffa and synergism when co-formulated with gentamicin.Keywords
This publication has 24 references indexed in Scilit:
- Wound healing effects of noni (Morinda citrifolia L.) leaves: a mechanism involving its PDGF/A2A receptor ligand binding and promotion of wound closurePhytotherapy Research, 2010
- Wound healing properties and kill kinetics ofClerodendron splendensG. Don, a ghanaian wound healing plantPharmacognosy Research, 2010
- Spathoside, a cerebroside and other antibacterial constituents of the stem bark ofSpathodea campanulataNatural Product Research, 2008
- Evaluation of Antioxidant and Wound Healing Effects of Alcoholic and Aqueous Extract ofOcimum sanctum Linnin RatsEvidence-Based Complementary and Alternative Medicine, 2008
- A Trafficking Pathway for Anthocyanins Overlaps with the Endoplasmic Reticulum-to-Vacuole Protein-Sorting Route in Arabidopsis and Contributes to the Formation of Vacuolar InclusionsPlant Physiology, 2007
- In vitro and in vivo evaluation of topical formulations of Spantide IIAAPS PharmSciTech, 2005
- Wound healing: an overview of acute, fibrotic and delayed healingFrontiers in Bioscience-Landmark, 2004
- Wound Microbiology and Associated Approaches to Wound ManagementClinical Microbiology Reviews, 2001
- Efficacy and safety of tea tree oil as a topical antimicrobial agentJournal of Hospital Infection, 1998
- Preparation and Structure of a Water‐in‐Oil Cream Containing Lipid NanoparticlesJournal of Pharmaceutical Sciences, 1995