Measurement of Interleukin-33 (IL-33) and IL-33 Receptors (sST2 and ST2L) in Patients with Rheumatoid Arthritis
Open Access
- 1 January 2011
- journal article
- Published by Korean Academy of Medical Sciences in Journal of Korean Medical Science
- Vol. 26 (9), 1132-1139
- https://doi.org/10.3346/jkms.2011.26.9.1132
Abstract
The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and fibrosis. It has been suggested that IL-33/ST2 signaling has been involved in the pathogenesis of rheumatoid arthritis (RA), because IL-33 and its receptor have been specifically mapped to RA synovium. The aim of this study was to determine the levels of IL-33 and sST2 in sera and synovial fluids in patients with RA. The serum level of IL-33 was significantly higher in patients with RA (294.9 ± 464.0 pg/mL) than in healthy controls (96.0 ± 236.9 pg/mL, P = 0.002). The synovial fluid level of IL-33 was significantly higher in RA patients than in osteoarthritis patients. The level of serum sST2 was higher in RA patients than in healthy controls (P = 0.042). A significant relationship was found between the levels of IL-33 and IL-1β (r = 0.311, P = 0.005), and IL-33 and IL-6 (r = 0.264, P = 0.017) in 81 RA patients. The levels of IL-33, sST2 and C-reactive protein decreased after conventional disease-modifying antirheumatic drugs treatment in 10 patients with treatment-naïve RA. Conclusively, IL-33 is involved in the pathogenesis of RA and may reflect the degree of inflammation in patients with RA.Keywords
This publication has 29 references indexed in Scilit:
- IL-33 Exacerbates Autoantibody-Induced ArthritisThe Journal of Immunology, 2010
- IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytesBiochemical and Biophysical Research Communications, 2009
- Interleukin-33 – cytokine of dual function or novel alarmin?Trends in Immunology, 2009
- The pro‐Th2 cytokine IL‐33 directly interacts with invariant NKT and NK cells to induce IFN‐γ productionEuropean Journal of Immunology, 2009
- Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophilsLaboratory Investigation, 2008
- Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cellsCytokine, 2007
- IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated CytokinesImmunity, 2005
- A Novel Therapy of Murine Collagen-Induced Arthritis with Soluble T1/ST2The Journal of Immunology, 2004
- T1/ST2—an IL-1 receptor-like modulator of immune responsesCytokine & Growth Factor Reviews, 2004
- Tissue Distribution and Subcellular Localization of a Variant Form of the Human ST2 Gene Product, ST2VBiochemical and Biophysical Research Communications, 2001