Biologically active compounds from European mistletoe (Viscum albumL.)1
- 1 March 2002
- journal article
- research article
- Published by Informa UK Limited in Canadian Journal of Plant Pathology
- Vol. 24 (1), 21-28
- https://doi.org/10.1080/07060660109506966
Abstract
European mistletoe (Viscum album L.) is a commonly occurring semiparasite of trees. The extracts from European mistletoe have been shown to possess immunostimulatory and cytotoxic activity on tumor cells, and are used in Europe in adjuvant cancer therapy. Recently, a number of studies performed have been leading to the identification and characterization of bioactive compounds. Apoptosis-inducing and ribosome-inactivating lectins as well as cytotoxic thionins (viscotoxins) are the main groups of compounds participating in biological activity of V. album. These compounds were isolated and studied in vitro and in vivo for their biological activity and mechanism of action. A comparison of the results to those using whole extracts indicated that lectins and viscotoxins are not the only bioactive compounds present in the mistletoe and among them, high heterogeneity is observed in both structure and activity. In this paper, we review the current state of the art in mistletoe studies, emphasizing its potential application as a drug, its standardization, and taxonomic problems. The nontherapeutic applications and suspected physiological functions of the compounds in question are also discussed briefly.Keywords
This publication has 55 references indexed in Scilit:
- Viscotoxin Composition of the three European Subspecies ofViscum albumPlanta Medica, 1998
- Isolation and partial characterization of a small chitin-binding lectin from mistletoe (Viscum album)FEBS Letters, 1996
- Selective disulphide linkage of plant thionins with other proteinsFEBS Letters, 1995
- Characterization of cytotoxic proteins from mistletoe (Viscum album L.)Cancer Letters, 1990
- The site of action of the A‐chain of mistletoe lectin I on eukaryotic ribosomes The RNA N‐glycosidase activity of the proteinFEBS Letters, 1988
- Thionins: Plant Peptides that Modify Membrane Permeability in Cultured Mammalian CellsEuropean Journal of Biochemistry, 1981
- Isolation of biologically active alkaloids from Korean mistletoeViscum album, coloratumCellular and Molecular Life Sciences, 1980
- Interaction Between DNA and Viscotoxins. Cytotoxic Basic Polypeptides fromViscum albumL.Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1980
- The Amino Acid Sequence of Viscotoxin A2 from the European Mistletoe (Viscum album L., Loranthaceae).Acta Chemica Scandinavica, 1972
- The Amino Acid Sequence of Oxidized Viscotoxin A3 from the European Mistletoe (Viscum album L, Loranthaceae).Acta Chemica Scandinavica, 1968