Strategies toward Dicarbofunctionalization of Unactivated Olefins by Combined Heck Carbometalation and Cross-Coupling
Top Cited Papers
- 16 March 2018
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 83 (6), 3013-3022
- https://doi.org/10.1021/acs.joc.7b03128
Abstract
The use of combined Heck carbometalation and cross-coupling remains one of the most powerful ways for the difunctionalization of unactivated olefins with organometallic reagents and organohalides. This synopsis will provide an overview of this reaction developed in the last three and a half decades. Herein, both the three-component and the two component cyclization/cross-coupling processes will be reviewed with a focus on strategies utilized to overcome the complications of beta-hydride elimination from Heck C(sp(3))-[M] intermediates, which usually functions as a major side reaction.Funding Information
- Division of Chemistry (CHE-1554299)
- University of New Mexico
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