Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii
- 1 April 2007
- journal article
- review article
- Published by Hindawi Limited in Cellular Microbiology
- Vol. 9 (4), 829-840
- https://doi.org/10.1111/j.1462-5822.2007.00901.x
Abstract
Most intracellular parasites employ sophisticated mechanisms to direct biogenesis of a vacuolar replicative niche that circumvents default maturation through the endolysosomal cascade. However, this is not the case of the Q fever bacterium, Coxiella burnetii. This hardy, obligate intracellular pathogen has evolved to not only survive, but to thrive, in the harshest of intracellular compartments: the phagolysosome. Following internalization, the nascent Coxiella phagosome ultimately develops into a large and spacious parasitophorous vacuole (PV) that acquires lysosomal characteristics such as acidic pH, acid hydrolases and cationic peptides, defences designed to rid the host of intruders. However, transit of Coxiella to this environment is initially stalled, a process that is apparently modulated by interactions with the autophagic pathway. Coxiella actively participates in biogenesis of its PV by synthesizing proteins that mediate phagosome stalling, autophagic interactions, and development and maintenance of the mature vacuole. Among the potential mechanisms mediating these processes is deployment of a type IV secretion system to deliver effector proteins to the host cytosol. Here we summarize our current understanding of the cellular events that occur during parasitism of host cells by Coxiella.Keywords
This publication has 128 references indexed in Scilit:
- A Legionella pneumophila -translocated substrate that is required for growth within macrophages and protection from host cell deathProceedings of the National Academy of Sciences of the United States of America, 2006
- Clinical and Pathologic Changes in a Guinea Pig Aerosol Challenge Model of Acute Q FeverInfection and Immunity, 2006
- NF-κB translocation prevents host cell death after low-dose challenge byLegionella pneumophilaThe Journal of Experimental Medicine, 2006
- Members of a Legionella pneumophila Family of Proteins with ExoU (Phospholipase A) Active Sites Are Translocated to Target CellsInfection and Immunity, 2006
- Coxiella burnetii inhabits a cholesterol-rich vacuole and influences cellular cholesterol metabolismCellular Microbiology, 2006
- Specificity ofLegionella pneumophilaandCoxiella burnetiiVacuoles and Versatility ofLegionella pneumophilaRevealed by CoinfectionInfection and Immunity, 2005
- IcmS‐dependent translocation of SdeA into macrophages by the Legionella pneumophila type IV secretion systemMolecular Microbiology, 2005
- Both Inducible Nitric Oxide Synthase and NADPH Oxidase Contribute to the Control of Virulent Phase ICoxiella burnetiiInfectionsInfection and Immunity, 2004
- Genetic Control of Natural Resistance of Mouse Macrophages to Coxiella burnetii Infection In Vitro: Macrophages from Restrictive Strains Control Parasitophorous Vacuole MaturationInfection and Immunity, 2004
- Electron microscopic studies of the rickettsia Coxiella burnetii: entry, lysosomal response, and fate of rickettsial DNA in L-cellsCanadian Journal of Microbiology, 1971