Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease
- 6 October 2017
- journal article
- review article
- Published by Elsevier BV in Free Radical Biology & Medicine
- Vol. 114, 40-51
- https://doi.org/10.1016/j.freeradbiomed.2017.10.001
Abstract
No abstract availableKeywords
Funding Information
- National Institute on Aging (NIA) (P01AG017617-16)
This publication has 208 references indexed in Scilit:
- Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer diseaseActa Neuropathologica, 2012
- Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndromeBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2012
- β‐ but not γ‐secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementiaEMBO Molecular Medicine, 2012
- Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's diseaseJournal of Chemical Neuroanatomy, 2011
- MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in betweenCurrent Opinion in Cell Biology, 2011
- Microarray Analysis of Hippocampal CA1 Neurons Implicates Early Endosomal Dysfunction During Alzheimer's Disease ProgressionBiological Psychiatry, 2010
- Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 MutationsCell, 2010
- Disease-Specific Induced Pluripotent Stem CellsCell, 2008
- Significant effect of APOE epsilon 4 genotype on the risk of dementia in Alzheimer's disease and mortality in persons with Down SyndromeInternational Journal of Geriatric Psychiatry, 2008
- BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic miceNeurobiology of Disease, 2007