The Value of Papanicolaou Tests in the Diagnosis of Endometrial Carcinoma
- 15 February 2016
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 145 (3), 350-354
- https://doi.org/10.1093/ajcp/aqv085
Abstract
Objectives: To determine on a large scale whether routine cervical Papanicolaou (Pap) tests play a role in endometrial carcinoma diagnosis. Methods: A retrospective search of an academic women’s hospital pathology archive for cases of surgically resected endometrial carcinoma with Pap smears within 36 months before the histologic diagnosis was performed. Demographic features, Pap test results, and tumor features were recorded. Results: We identified 554 (30.5%) of 1,817 cases of endometrial carcinoma with documented Pap test results within 36 months before histologic diagnosis. Among these 554 patients, 405 (73.0%) had Pap test results within 5 months before histologic diagnosis. In total, 154 (38%) cases demonstrated abnormal glandular cells, and 25 (6.2%) had only benign endometrial cells in women 40 years or older. The presence of glandular abnormality on the Pap test is significantly correlated with tumor size, tumor type, depth of invasion, presence of cervical involvement, and presence of lymphovascular invasion (P < .05). The rate of detecting abnormal glandular cells was higher in cases with a high International Federation of Gynecology and Obstetrics (FIGO) stage than in cases with a low FIGO stage (47.5% vs 35.5%; P < .05). Conclusions: The Pap test may play a role in the detection of endometrial carcinoma, especially for those with cervical involvement, lymphovascular invasion, and/or advanced stage.Keywords
This publication has 19 references indexed in Scilit:
- Histologic Follow-up in Patients With Papanicolaou Test Findings of Endometrial CellsAmerican Journal of Clinical Pathology, 2012
- Liquid-Based Papanicolaou Tests in Endometrial Carcinoma DiagnosisAmerican Journal of Clinical Pathology, 2012
- Nuclear characteristics of the endometrial cytology: Liquid‐based versus conventional preparationDiagnostic Cytopathology, 2011
- Abnormal Cervical Cytology in the Diagnosis of Uterine Papillary Serous Carcinoma: Earlier Detection of a Poor Prognostic Cancer SubtypeActa Cytologica, 2011
- Endometrial carcinoma detected with SurePath liquid‐based cervical cytology: comparison with conventional cytologyCytopathology, 2009
- Histologic follow-up results in 662 patients with Pap test findings of atypical glandular cells: Results from a large academic womens hospital laboratory employing sensitive screening methodsGynecologic Oncology, 2009
- ThinPrep Pap tests in patients with endometrial cancer: A histo‐cytological correlationDiagnostic Cytopathology, 2007
- Diagnostic Value of the Thin-Layer, Liquid-Based Pap Test in Endometrial CancerActa Cytologica, 2007
- Rate of Pathology From Atypical Glandular Cell Pap Tests Classified by the Bethesda 2001 NomenclatureObstetrics & Gynecology, 2006
- Clinical Significance of Atypical Glandular Cells on Cervical CytologyObstetrics & Gynecology, 2006