Why Calcium-Stimulated Adenylyl Cyclases?
Open Access
- 1 October 2004
- journal article
- review article
- Published by American Physiological Society in Physiology
- Vol. 19 (5), 271-276
- https://doi.org/10.1152/physiol.00010.2004
Abstract
The Ca2+/calmodulin-stimulated adenylyl cyclases, AC1 and AC8, play a critical role in several forms of neuroplasticity, including long-lasting long-term potentiation (L-LTP) and long-term memory (LTM). By coupling neuronal activity and Ca2+increases to the production of cAMP, AC1 and AC8 activate cAMP-dependent signal transduction and transcriptional pathways critical for L-LTP and LTM.Keywords
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