Optimising Treatment of Elderly Patients with Ovarian Cancer
- 1 January 2005
- journal article
- review article
- Published by Springer Science and Business Media LLC in Drugs & Aging
- Vol. 22 (2), 95-100
- https://doi.org/10.2165/00002512-200522020-00001
Abstract
The aging population is the fastest growing segment of our population. Over the last century, the average life expectancy has increased by 25 years. The incidence of ovarian carcinoma, seen primarily in postmenopausal women, is, therefore, expected to increase. The current standard treatment of ovarian cancer has been determined on the basis of prospective, randomised clinical trials carried out by cooperative groups. Sixty-one percent of new cancer cases occur in women >65 years of age. Despite this fact, enrolment in clinical trials has been exceedingly low. In turn, this causes suboptimal treatment for a very fatal disease. The aetiology of this is multifactorial, and strategies for improvement are lacking. Elderly patients may be barred from participation based on physician biases alone. Elderly patients may have limited access to academic centres where clinical trials are conducted or be excluded on the basis of unrealistic inclusion criteria. As physicians, it is our duty to understand the elderly patient and the comorbidities in this age group that may influence the tolerability and toxicity of conventional therapies. Therefore, it is imperative that we make a conscious effort to examine ways in which we may improve enrolment of elderly women with ovarian cancer in clinical trials.Keywords
This publication has 18 references indexed in Scilit:
- Age as a prognostic factor in ovarian carcinoma: The gynecologic oncology group experienceCancer, 2010
- An assessment of age and other factors influencing protocol versus alternative treatments for patients with epithelial ovarian cancer referred to member institutions: a Gynecologic Oncology Group studyGynecologic Oncology, 2004
- Interventions to Improve Medication Compliance in Older Patients Living in the CommunityDrugs & Aging, 2003
- A randomized controlled trial of early oral analgesia in gynecologic oncology patients undergoing intra-abdominal surgeryObstetrics & Gynecology, 2002
- Underrepresentation of Patients 65 Years of Age or Older in Cancer-Treatment TrialsThe New England Journal of Medicine, 1999
- A Randomized Controlled Trial of Early Postoperative Feeding in Gynecologic Oncology Patients Undergoing Intra-abdominal SurgeryObstetrics & Gynecology, 1998
- A randomized controlled trial of postoperative nasogastric tube decompression in gynecologic oncology patients undergoing intra-abdominal surgeryObstetrics & Gynecology, 1996
- Clinical Trials and Clinical Practice in the ElderlyDrugs & Aging, 1992
- Serum albumin: Its relationship to marrow and renal toxicity from platinum-based combination chemotherapyGynecologic Oncology, 1990
- Research Challenges, New Drug Development, Preclinical and Clinical Trials in the Ageing PopulationDrug Safety, 1990