Leptin and the brain: then and now
Open Access
- 3 June 2013
- journal article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 123 (6), 2344-2345
- https://doi.org/10.1172/jci69346
Abstract
The discovery of the adipocyte hormone leptin and the demonstration that severe obesity in ob/ob and db/db mice results from mutation of genes encoding leptin and its receptor, respectively, ushered in a new era of obesity research. Our investigation into mechanisms mediating CNS actions of insulin led us to ask whether the two hormones act on a common set of hypothalamic targets. Our finding that this is indeed the case prompted studies that continue to this day. While substantial progress has been made in understanding brain mechanisms of leptin action, translating this knowledge into more effective treatment of obesity remains an elusive goal.This publication has 20 references indexed in Scilit:
- Central Nervous System Mechanisms Linking the Consumption of Palatable High-Fat Diets to the Defense of Greater AdiposityCell Metabolism, 2012
- Obesity is associated with hypothalamic injury in rodents and humansJCI Insight, 2012
- Obesity and leptin resistance: distinguishing cause from effectTrends in Endocrinology & Metabolism, 2010
- The Neuroanatomical Axis for Control of Energy BalanceFrontiers in Neuroendocrinology, 2002
- Identification of targets of leptin action in rat hypothalamus.JCI Insight, 1996
- Identification and expression cloning of a leptin receptor, OB-RCell, 1995
- Positional cloning of the mouse obese gene and its human homologueNature, 1994
- Inhibition of hypothalamic neuropeptide Y gene expression by insulinEndocrinology, 1992
- Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboonsNature, 1979
- Effects of parabiosis of obese with diabetes and normal miceDiabetologia, 1973