Recent Advances in Photoacoustic Imaging for Deep-Tissue Biomedical Applications
- 1 January 2016
- journal article
- review article
- Published by Ivyspring International Publisher in Theranostics
- Vol. 6 (13), 2394-2413
- https://doi.org/10.7150/thno.16715
Abstract
Photoacoustic imaging (PAI), a novel imaging modality based on photoacoustic effect, shows great promise in biomedical applications. By converting pulsed laser excitation into ultrasonic emission, PAI combines the advantages of optical imaging and ultrasound imaging, which benefits rich contrast, high resolution and deep tissue penetration. In this paper, we introduced recent advances of contrast agents, applications, and signal enhancement strategies for PAI. The PA contrast agents were categorized by their components, mainly including inorganic and organic PA contrast agents. The applications of PAI were summarized as follows: deep tumor imaging, therapeutic responses monitoring, metabolic imaging, pH detection, enzyme detection, reactive oxygen species (ROS) detection, metal ions detection, and so on. The enhancement strategies of PA signals were highlighted. In the end, we elaborated on the challenges and provided perspectives of PAI for deep-tissue biomedical applications.Keywords
This publication has 110 references indexed in Scilit:
- Upconverting Organic Dye Doped Core-Shell Nano-Composites for Dual-Modality NIR Imaging and Photo-Thermal TherapyTheranostics, 2013
- Family of Enhanced Photoacoustic Imaging Agents for High-Sensitivity and Multiplexing Studies in Living MiceACS Nano, 2012
- Deep‐Tissue Photoacoustic Tomography of a Genetically Encoded Near‐Infrared Fluorescent ProbeAngewandte Chemie-International Edition, 2011
- Boronate Oxidation as a Bioorthogonal Reaction Approach for Studying the Chemistry of Hydrogen Peroxide in Living SystemsAccounts of Chemical Research, 2011
- Copper Selenide Nanocrystals for Photothermal TherapyNano Letters, 2011
- Ultrahigh Sensitivity Carbon Nanotube Agents for Photoacoustic Molecular Imaging in Living MiceNano Letters, 2010
- Matrix Metalloproteinases: Regulators of the Tumor MicroenvironmentCell, 2010
- In Vivo Photoacoustic Tomography of Chemicals: High-Resolution Functional and Molecular Optical Imaging at New DepthsChemical Reviews, 2010
- Multifunctional quantum dots for personalized medicineNano Today, 2009
- PEGylated Nanographene Oxide for Delivery of Water-Insoluble Cancer DrugsJournal of the American Chemical Society, 2008