The HTLV-1 Tax interactome
Open Access
- 14 August 2008
- journal article
- review article
- Published by Springer Science and Business Media LLC in Retrovirology
- Vol. 5 (1), 76
- https://doi.org/10.1186/1742-4690-5-76
Abstract
The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.Keywords
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