Thymic stromal lymphopoietin in normal and pathogenic T cell development and function
- 19 June 2006
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Immunology
- Vol. 7 (7), 709-714
- https://doi.org/10.1038/ni1360
Abstract
Thymic stromal lymphopoietin, a four helix–bundle cytokine, is expressed mainly by barrier epithelial cells and is a potent activator of several cell types, particularly myeloid dendritic cells. TSLP influences the outcome of interactions between dendritic cells and CD4+ thymocytes and T cells in many situations, such as the regulation of the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and induction of CD4+ T cell–mediated allergic inflammation.Keywords
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