An explanatory randomised placebo controlled trial of levothyroxine supplementation for babies born <28 weeks’ gestation: results of the TIPIT trial
Open Access
- 1 January 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in Trials
- Vol. 14 (1), 211
- https://doi.org/10.1186/1745-6215-14-211
Abstract
Babies born before 28 weeks’ gestation have lower plasma thyroid hormone concentrations than more mature infants. This may contribute to their risk of poor developmental outcome. Previous studies have suggested that thyroxine supplementation for extremely preterm neonates may be beneficial. The aim of this study was to investigate the effect of administration of supplemental thyroxine to very premature babies on brain size and somatic growth at 36 weeks’ corrected gestational age (CGA).This publication has 33 references indexed in Scilit:
- Transient hypothyroxinaemia in preterm infantsEarly Human Development, 2006
- Developmental Trends in Cord and Postpartum Serum Thyroid Hormones in Preterm InfantsJournal of Clinical Endocrinology & Metabolism, 2004
- A Longitudinal Assessment of Thyroid Hormone Concentrations in Preterm Infants Younger Than 30 Weeks’ Gestation During the First 2 Weeks of Life and Their Relationship to OutcomePEDIATRICS, 2002
- The Influence of Etiology and Treatment Factors on Intellectual Outcome in Congenital HypothyroidismJournal of Developmental & Behavioral Pediatrics, 2001
- Intellectual outcome at 12 years of age in congenital hypothyroidismActa Endocrinologica, 1999
- Thyroid Function in the Preterm InfantThyroid®, 1999
- Thyroid Function in Very Preterm Infants: Influences of Gestational Age and DiseasePediatric Research, 1997
- Low triiodothyronine concentration in preterm infants and subsequent intelligence quotient (IQ) at 8 year follow upBMJ, 1996
- Results of controlled double-blind study of thyroid replacement in very low-birth-weight premature infants with hypothyroxinemia1984
- Thyroid Development and Disorders of Thyroid Function in the NewbornThe New England Journal of Medicine, 1981