Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery
Top Cited Papers
Open Access
- 24 September 2011
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 40 (D1), D1128-D1136
- https://doi.org/10.1093/nar/gkr797
Abstract
Knowledge and investigation of therapeutic targets (responsible for drug efficacy) and the targeted drugs facilitate target and drug discovery and validation. Therapeutic Target Database (TTD, http://bidd.nus.edu.sg/group/ttd/ttd.asp) has been developed to provide comprehensive information about efficacy targets and the corresponding approved, clinical trial and investigative drugs. Since its last update, major improvements and updates have been made to TTD. In addition to the significant increase of data content (from 1894 targets and 5028 drugs to 2025 targets and 17 816 drugs), we added target validation information (drug potency against target, effect against disease models and effect of target knockout, knockdown or genetic variations) for 932 targets, and 841 quantitative structure activity relationship models for active compounds of 228 chemical types against 121 targets. Moreover, we added the data from our previous drug studies including 3681 multi-target agents against 108 target pairs, 116 drug combinations with their synergistic, additive, antagonistic, potentiative or reductive mechanisms, 1427 natural product-derived approved, clinical trial and pre-clinical drugs and cross-links to the clinical trial information page in the ClinicalTrials.gov database for 770 clinical trial drugs. These updates are useful for facilitating target discovery and validation, drug lead discovery and optimization, and the development of multi-target drugs and drug combinations.This publication has 53 references indexed in Scilit:
- Clustered patterns of species origins of nature-derived drugs and clues for future bioprospectingProceedings of the National Academy of Sciences of the United States of America, 2011
- DrugBank 3.0: a comprehensive resource for 'Omics' research on drugsNucleic Acids Research, 2010
- Update of TTD: Therapeutic Target DatabaseNucleic Acids Research, 2009
- Plant-derived compounds in clinical trialsDrug Discovery Today, 2008
- Natural Products as Sources of New Drugs over the Last 25 YearsJournal of Natural Products, 2007
- Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3Nature, 2007
- BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinitiesNucleic Acids Research, 2006
- How many drug targets are there?Nature Reviews Drug Discovery, 2006
- Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapyNature Reviews Cancer, 2006
- Multicomponent therapeutics for networked systemsNature Reviews Drug Discovery, 2005