Analgesia from Electrical Stimulation in the Brainstem of the Rat
- 24 December 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 174 (4016), 1351-1354
- https://doi.org/10.1126/science.174.4016.1351
Abstract
Stimulation at several mesencephalic and diencephalic sites abolished responsiveness to intense pain in rats while leaving responsiveness to other sensory modes relatively unaffected. The peripheral field of analgesia was usually restricted to one-half or to one quadrant of the body, and painful stimuli applied outside this field elicited a normal reaction. Analgesia outlasted stimulation by up to 5 minutes. Most electrode placements that produced analgesia also supported self-stimulation.One placement supported self-stimulation only in the presence of pain.Keywords
This publication has 11 references indexed in Scilit:
- Motivational effects of electrical stimulation in dorsal tegmentum of the ratPhysiology & Behavior, 1971
- Enhancement by morphine of the central descending inhibitory influence on spinal sensory transmissionEuropean Journal of Pharmacology, 1971
- Somatosensory evoked responses in the mesencephalic central gray matter of the ratBrain Research, 1971
- On the central sites for the antinociceptive action of morphine and fentanylNeuropharmacology, 1970
- Mesencephalic central gray lesions and fear-motivated behavior in ratsBrain Research, 1970
- Alteration in footshock threshold by low-level septal brain stimulationPhysiology & Behavior, 1970
- Surgery in the Rat during Electrical Analgesia Induced by Focal Brain StimulationScience, 1969
- An Inquiry into the Neurophysiological Basis for PainJournal of Neurosurgery, 1969
- Pain Mechanisms: A New TheoryScience, 1965
- Attenuation of Aversive Properties of Peripheral Shock by Hypothalamic StimulationScience, 1965