BCL-2 FAMILY: Regulators of Cell Death
- 1 April 1998
- journal article
- review article
- Published by Annual Reviews in Annual Review of Immunology
- Vol. 16 (1), 395-419
- https://doi.org/10.1146/annurev.immunol.16.1.395
Abstract
▪ Abstract An expanding family of BCL-2 related proteins share homology, clustered within four conserved regions, namely BCL-2 homology (BH1-4) domains, which control the ability of these proteins to dimerize and function as regulators of apoptosis. Moreover, BCL-XL, BCL-2, and BAX can form ion-conductive pores in artificial membranes. The BCL-2 family, comprised of both pro-apoptotic and anti-apoptotic members, acts as a checkpoint upstream of CASPASES and mitochondrial dysfunction. BID and BAD possess the minimal death domain BH3, and the phosphorylation of BAD connects proximal survival signals to the BCL-2 family. BCL-2 and BCL-XLdisplay a reciprocal pattern of expression during lymphocyte development. Gain- and loss-of-function models revealed stage-specific roles for BCL-2 and BCL-XL. BCL-2 can rescue maturation at several points of lymphocyte development. The BCL-2 family also reveals evidence for a cell-autonomous coordination between the opposing pathways of proliferation and cell death.Keywords
This publication has 95 references indexed in Scilit:
- Structure of Bcl-x L -Bak Peptide Complex: Recognition Between Regulators of ApoptosisScience, 1997
- Bcl-xL forms an ion channel in synthetic lipid membranesNature, 1997
- A Peptide Sequence from Bax That Converts Bcl-2 into an Activator of ApoptosisOnline Journal of Public Health Informatics, 1996
- Oncogenes and cell deathCurrent Opinion in Genetics & Development, 1994
- Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3Cell, 1993
- The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzymeCell, 1993
- Control of Larval Development by Chemosensory Neurons in Caenorhabditis elegansScience, 1991
- Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell deathNature, 1990
- The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lckCell, 1988
- Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18Cell, 1985