Frequency and predictors of hypoglycaemia in Type 1 and insulin‐treated Type 2 diabetes: a population‐based study
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- 21 May 2005
- journal article
- clinical trial
- Published by Wiley in Diabetic Medicine
- Vol. 22 (6), 749-755
- https://doi.org/10.1111/j.1464-5491.2005.01501.x
Abstract
To ascertain the frequency and identify predictors of self-reported hypoglycaemia in Type 1 and insulin-treated Type 2 diabetes. A random sample of 267 people with insulin-treated diabetes were recruited from a population-based diabetes register in Tayside, Scotland. Each subject prospectively recorded the number of mild and severe hypoglycaemic episodes experienced over a 1-month period. Ordinal logistic regression was performed to identify potential predictors of hypoglycaemia. Five hundred and seventy-two hypoglycaemic events were reported by 155 patients. The participants with Type 1 diabetes had a total of 336 hypoglycaemic events with a rate of 42.89 events per patient per year. Of these, nine were severe hypoglycaemic events, with a rate of 1.15 events per patient per year. Participants with insulin-treated Type 2 diabetes experienced a total of 236 hypoglycaemic events with a rate of 16.37 events per patient per year. Of these, five were severe hypoglycaemic events, which would be equivalent to 0.35 events per patient per year. Predictors of hypoglycaemia in Type 1 diabetes were a history of previous hypoglycaemia (P = 0.006) and co-prescribing of any oral drug (P = 0.048). In patients with insulin-treated Type 2 diabetes, a history of previous hypoglycaemia (P < 0.0001) and duration of insulin treatment (P = 0.014) were significant predictors. The incidence of self-reported severe hypoglycaemia in insulin-treated Type 2 diabetes is lower than in Type 1 diabetes but does occur more often than previously reported and with sufficient frequency to cause significant morbidity. Duration of insulin treatment is a key predictor of hypoglycaemia in insulin-treated Type 2 diabetes.Keywords
This publication has 26 references indexed in Scilit:
- Assessment of hypoglycaemia awareness using continuous glucose monitoringDiabetic Medicine, 2004
- Clinical characteristics of type 1 diabetic patients with and without severe hypoglycemia.Diabetes Care, 2000
- Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)The Lancet, 1998
- Reduced Awareness of Hypoglycemia in Adults With IDDM: A prospective study of hypoglycemic frequency and associated symptomsDiabetes Care, 1995
- Frequency, Severity and Symptomatology of Hypoglycaemia: a Comparative Trial of Human and Porcine Insulins in Type 1 Diabetic PatientsDiabetic Medicine, 1995
- Frequency of Severe Hypoglycemia in Patients With Type I Diabetes With Impaired Awareness of HypoglycemiaDiabetes Care, 1994
- Frequency and Morbidity of Severe Hypoglycaemia in Insulin‐treated Diabetic PatientsDiabetic Medicine, 1993
- Symptomatic Hypoglycaemia in 411 Type 1 Diabetic PatientsDiabetic Medicine, 1991
- The Value of Cardiovascular Autonomic Function Tests: 10 Years Experience in DiabetesDiabetes Care, 1985
- Insulin-induced hypoglycaemia in an accident and emergency department: the tip of an iceberg?BMJ, 1982