Quantitative Two‐Dimensional time Correlation Relaxometry

Abstract

An experimental and analytical method is presented for obtaining two-dimensional NMR time correlation spectra of T₁ and (T₂ and T₂) exponential relaxation in heterogeneous samples. The numerical algorithms used in this study do not bias the solution by any a priori assumptions as to the number of required components. The constraints used to overcome the ill-posed and ill-conditioned nature of this inverse problem are also described. With this method, the correlations of T₁ (or T₁) and T₂ exponential components in systems of nonexchanging standards and rat muscle tissues are obtained. © 1991 Academic Press, Inc.