Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances
Top Cited Papers
- 13 June 2017
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 60 (19), 7941-7957
- https://doi.org/10.1021/acs.jmedchem.6b01720
Abstract
The use of privileged structures in drug discovery has proven to be an effective strategy, allowing the generation of innovative hits/leads and successful optimization processes. Chromone is recognized as a privileged structure and a useful template for the design of novel compounds with potential pharmacological interest, particularly in the field of neurodegenerative, inflammatory, and infectious diseases as well as diabetes and cancer. This perspective provides the reader with an update of an earlier article entitled "Chromone: A Valid Scaffold in Medicinal Chemistry" ( Chem. Rev. 2014 , 114 , 4960 - 4992 ) and is mainly focused on chromones of biological interest, including those isolated from natural sources. Moreover, as drug repurposing is becoming an attractive drug discovery approach, recent repurposing studies of chromone-based drugs are also reported.Keywords
Funding Information
- European Cooperation in Science and Technology (CA15135)
- Funda??o para a Ci?ncia e a Tecnologia (POCI-01-0145-FEDER-006980, SFRH/BD/96033/2013, SFRH/BPD/93331/2013, UID/QUI/UI0081/2013)
- Programa Operacional Potencial Humano
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