Risk factors for mortality in patients with Coronavirus disease 2019 (COVID-19) infection: a systematic review and meta-analysis of observational studies
- 8 June 2020
- journal article
- review article
- Published by Informa UK Limited in The Aging Male
- Vol. 23 (5), 1416-1424
- https://doi.org/10.1080/13685538.2020.1774748
Abstract
Purpose: Coronavirus disease 2019 (COVID-19) is an emerging disease that was first reported in Wuhan city, the capital of Hubei province in China, and has subsequently spread worldwide. Risk factors for mortality have not been well summarized. Current meta-analysis of retrospective cohort studies was done to summarize available findings on the association between age, gender, comorbidities and risk of death from COVID-19 infection. Methods: Online databases including Web of Science, PubMed, Scopus, Cochrane Library and Google scholar were searched to detect relevant publications up to 1 May 2020, using relevant keywords. To pool data, random-effects model was used. Furthermore, sensitivity analysis and publication bias test were also done. Results: In total, 14 studies with 29,909 COVID-19 infected patients and 1445 cases of death were included in the current meta-analysis. Significant associations were found between older age (≥65 vs p < .001), gender (male vs female) (pooled ORs = 1.50, 95%CIs = 1.06–2.12, p = .021) and risk of death from COVID-19 infection. In addition, hypertension (pooled ORs = 2.70, 95%CIs = 1.40–5.24, p = .003), cardiovascular diseases (CVDs) (pooled ORs = 3.72, 95%CIs = 1.77–7.83, p = .001), diabetes (pooled ORs = 2.41, 95%CIs = 1.05–5.51, p = .037), chronic obstructive pulmonary disease (COPD) (pooled ORs = 3.53, 95%CIs = 1.79–6.96, p < .001) and cancer (pooled ORs = 3.04, 95%CIs = 1.80–5.14, p < .001), were associated with higher risk of mortality. Conclusions: Older age (≥65 years old), male gender, hypertension, CVDs, diabetes, COPD and malignancies were associated with greater risk of death from COVID-19 infection. These findings could help clinicians to identify patients with poor prognosis at an early stage.Keywords
This publication has 47 references indexed in Scilit:
- Populations at risk for severe or complicated influenza illness: systematic review and meta-analysisBMJ, 2013
- Emerging markers in cardiovascular disease: Where does angiotensin‐converting enzyme 2 fit in?Clinical and Experimental Pharmacology and Physiology, 2013
- Convincing Evidence from Controlled and Uncontrolled Studies on the Lipid-Lowering Effect of a StatinPublished by Wiley ,2012
- Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analysesEuropean Journal of Epidemiology, 2010
- Binding of SARS coronavirus to its receptor damages islets and causes acute diabetesActa Diabetologica, 2009
- Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARSDiabetic Medicine, 2006
- The Immunopathogenesis of Sepsis in Elderly PatientsClinical Infectious Diseases, 2005
- Outcomes and Prognostic Factors in 267 Patients with Severe Acute Respiratory Syndrome in Hong KongAnnals of Internal Medicine, 2003
- Acute Respiratory Distress Syndrome in Critically Ill Patients With Severe Acute Respiratory SyndromeJAMA, 2003